Trametinib is an oral drug that is administered in combination with dabrafenib.
How to administer it
The dose is 2 mg once a day. It must be taken by mouth with a full glass of water. The tablets should not be chewed or crushed and should be taken without food (at least 1 hour before or 2 hours after eating).
It is recommended that trametinib is taken at the same time each day. When trametinib and dabrafenib are taken in combination, the single daily dose of trametinib must be taken at the same time each day or with the morning or evening dose of dabrafenib.
If you experience vomiting after taking them, it is not recommended to take the second dose.
Possible side effects of Trametinib
- Constipation
- Cough
- Loss of appetite
- Diarrhea
- Dry skin
- Muscle or joint pain
- Nausea
- Fatigue
- Rash (may resemble acne)
- Mouth sores or blisters
- Cramps, weakness or muscle pain
Fertility, pregnancy and breastfeeding
Women are recommended to not become pregnant and men to refrain from conceiving children during treatment with trametinib as it may harm the baby.
If there is a possibility that the person taking this drug may become pregnant or become a father, they should use a valid contraceptive method for the duration of the treatment and for at least 90 days after its completion since oral contraceptives may not be effective when taken concomitantly with trametinib.
